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Spicy Cajun Chicken Alfredo Bake

Creamy baked Alfredo pasta loaded with juicy Cajun chicken, melted cheese, and bold smoky seasoning for the ultimate comfort food dinner.
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Prep Time 20 minutes
Cook Time 30 minutes
Total Time 50 minutes
Servings: 8 servings
Course: Dinner, Main Course
Cuisine: American, Cajun
Calories: 710
Ingredients Equipment Method Notes

Ingredients
  

Chicken
  • 2 large chicken breasts sliced
  • 2 tbsp olive oil
  • 2 tbsp Cajun seasoning
  • 1 tsp garlic powder
  • 1 tsp paprika
  • 1 tsp salt to taste
  • 0.5 tsp black pepper to taste
Alfredo Pasta
  • 12 oz penne pasta
  • 3 tbsp butter
  • 4 cloves garlic minced
  • 2 cups heavy cream
  • 1 cup whole milk
  • 1.5 cups parmesan cheese grated
  • 2 cups mozzarella cheese shredded
  • 1 tsp Italian seasoning
  • 0.5 tsp red pepper flakes

Equipment

  • Large skillet
  • Large pot
  • Baking dish
  • Mixing bowls

Method
 

  1. Preheat oven to 375°F (190°C) and grease a baking dish.
  2. Cook pasta until al dente and drain.
  3. Season chicken with Cajun seasoning, paprika, garlic powder, salt, and pepper.
  4. Cook chicken in olive oil until golden and fully cooked.
  5. Melt butter in skillet and sauté garlic.
  6. Add heavy cream and milk, then stir in parmesan cheese until smooth.
  7. Season Alfredo sauce with Italian seasoning and red pepper flakes.
  8. Combine pasta, sauce, and chicken together.
  9. Transfer to baking dish, top with mozzarella cheese, and bake until bubbly.

Notes

Add bacon, shrimp, or spinach for delicious variations. Best served hot with garlic bread or salad.